Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Antileukemic Agents. I. Some 2, 5-Disubstituted p-Benzoquinones
HIDEO NAKAOMASAO ARAKAWA
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1972 Volume 20 Issue 9 Pages 1962-1967

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Abstract
A series of p-benzoquinone derivatives having one or two carbamoyloxyalkyl groups in the 2 and/or 5-positions were synthesized and evaluated as antileukemic agents. Among these compounds 2, 5-bis (1-aziridinyl)-3-(2-carbamoyloxyethyl)-6-methyl-p-benzoquinone (21) showed high activity against lymphoid leukemia L-1210 in BDF1 mice.
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© The Pharmaceutical Society of Japan
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