Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Antileukemic Agents. II. New 2, 5-Bis (1-aziridinyl)-p-benzoquinone Derivatives
HIDEO NAKAOMASAO ARAKAWATAKAHIRO NAKAMURAMASAMI FUKUSHIMA
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1972 Volume 20 Issue 9 Pages 1968-1979

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Abstract
A series of 2, 5-bis (1-aziridinyl)-p-benzoquinone derivatives were synthesized and evaluated as antileukemic agents. The most active compounds against lymphoid leukemia L-1210 in BDF1 mice were 2, 5-bis (1-aziridinyl)-3-(2-carbamoyloxyethyl-1-methoxy)-6-methyl-p-benzoquinone, carbazilquinone (7), and related compounds (8, 23 and 24). Structure-activity relationships were discussed.
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© The Pharmaceutical Society of Japan
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