抄録
1. Aniline-induced difference spectrum in post-mortem human liver microsomes was recognized as type II similar to that in rat liver. Hexobarbital- and aminopyrineinduced P-450 difference spectra were also of type II in human, but they were different from those in rat liver microsomes.
2. There was no correlation between enzyme activities of the NADPH-linked electron transport system in liver microsomes and aniline hydroxylase activity in human liver, which was similar to that of rat liver. The activity of hydroxylation. of hexobarbital, a type I compound, in human was lower than that in rat liver, and a similar result was observed when aminopyrine was used as substrate.
