Isobornyloxycarbonyl Function, a New Convenient Amino-Protecting Group in Peptide Synthesis. IV. Synthesis of Gonadotropin-Releasing Hormone (Gn-RH or LH-RII/FSH-RH)
Gonadotropin-releasing hormone (Gn-RH or LH-RH/FSH-RH), a decapeptide amide (Pyr) Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2, was synthesized by the use of the d-isobornyloxycarbonyl-protercting group for temporary protection of the all amino groups of the intermediary peptides. The synthetic Gn-RH possessed full biological activity (LH-releasing and FSH-releasing activity) when compared with natural highly purified porcine Gn-RH, and appeared to be pure by various chemical criteria.
