Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on Organic Sulfur Compounds. XI. Synthesis of 2-Alkylthio-thiazolo [3, 2-a]-s-triazine-4-ones
MITSUO NAGANOTAKASHI MATSUIJUNZO TOBITSUKAKOZO OYAMADA
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1973 年 21 巻 1 号 p. 74-86

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1-Alkoxycarbonyl-3-(2-thiazolyl) thioureas (A) were reacted with alkyl halides in presence of potassium carbonate to afford 1 (H)-alkoxycarbony1-2-alkyl-3-(2-thiazolyl)-isothioureas (D), 1-alkoxycarbony1-2-alkyl-3-(3-alkylthiazolin-2-ylidene) isothioureas (E) 2-alkylthio-thiazolo [3, 2-a]-s-triazine-4-ones (C). However, the rate of this reaction the yields of the products were dependent on the kinds of alkyl halide and thiazolyl thioureas (A). The cyclization products (C) were obtained in a good yield by the thermal treatment of the compounds (E).
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