Reaction of Biguanides and Related Compounds. VI. Condensation of N-Amidino-O-alkylisourea with β-Diketone

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N-Amidino-O-alkylisourea was allowed to react with acetylacetone and benzoylacetone. Heating of N-amidino-O-alkylisourea with acetylacetone in boiling ethanol gave 2-alkoxy-4-amino-6-methyl-sym-triazine. On the other hand, the same reaction at room temperature gave 2-alkoxyamidino-4, 6-dimethylpyrimidine. The reaction of N amidino-O-alkylisourea with benzoylacetone in boiling ethanol afforded 2-amino-6-methyl-4-phenylpyrimidine. Difference of the reactivity in these reactions was also discussed.