Abstract
Three penta-N-phenylalkylideneaminosidins, two penta-N-phenylalkylaminosidins, and two N-methylaminosidins were prepared, and their antimicrobial activities in vitro were determined. Penta-N-phenylalkylideneaminosidins had antimicrobial activity approximatelyequal to or slightly less than that of aminosidin. However, penta-N-phenylalkylaminosidinsand N-methylaminosidins were devoid of antimicrobial activity.
Penta-N-benzylideneaminosidin protected mice from death by Staphylococcus aureus and Escherichia coli infections, and acute toxicity of the penta-N-benzylideneaminosidin was less than that of aminosidin by a subcutaneous route.
