Synthesis of Bradykinyl-Val-Ala-Pro-Ala-Ser-OH and Its Biological Properties

Abstract

Synthesis is described of bradykinyl-Val-Ala-Pro-Ala-Ser-OH.All the fragment condensations were carried out by Rudinger's azide method in order to minimize the racemization during the coupling steps involving peptide fragments. The ensuing tetradecapeptide with a high degree of homogeneity was found to be identical with bradykinyl-Val-Ala-Pro-Ala-Ser-OH of natural origin with respect to chemical and biological properties.