Chemistry of Diborane and Sodium Borohydride. X. The Reduction of 2-or 4-Substituted Pyridines and Quinolines, and 1-or 3-Substituted Isoquinolines with Sodium Borohydride

Abstract

The reaction of 2-or 4-substituted pyridines and quinolines and 1-or 3-substituted isoquinolines with sodium borohydride was examined. The substituent groups which are usually resistant to reduction with sodium borohydride were reducible through the electronic influence of the heteromatic ring. The solvent effects on the reduction with sodium borohydride were also examined.