Abstract
The water-soluble polysaccharides of several kinds of lichens of Stictaceae, especially Lobaria orientalis, have been studied chemically in the relation with their host-mediated antitumour activities agamst sarcoma 180 in mice. L. orientalis contains at least two glycopeptides, LOF-1 and -2, which are the first example of the antitumour active glycopeptides found in lichens. The carbohydrate moiety of LOF-1 consists of 1→6 glucan and 1→3 mannan, which is linked with serine and threonine of the peptide part by O-glycosyl linkages.
