Chemical Structure of QAII, One of the Covalently Bound Adducts of Carcinogenic 4-Nitroquinoline 1-Oxide with Nucleic Acid Bases of Cellular Nucleic Acids

YUTAKA KAWAZOE; MISAKO ARAKI; GUANGFU HUANG; TOSHIHIKO OKAMOTO; MITSUHIKO TADA; MARIKO TADA

doi:10.1248/cpb.23.3041

Chemical Structure of QA_II, One of the Covalently Bound Adducts of Carcinogenic 4-Nitroquinoline 1-Oxide with Nucleic Acid Bases of Cellular Nucleic Acids

YUTAKA KAWAZOE, MISAKO ARAKI, GUANGFU HUANG, TOSHIHIKO OKAMOTO, MITSUHIKO TADA, MARIKO TADA

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JOURNAL FREE ACCESS

1975 Volume 23 Issue 11 Pages 3041-3043

DOI https://doi.org/10.1248/cpb.23.3041

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Abstract

The chemical structure of the quinoline-adenine adduct, QA_II, which was isolated from deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) extracted from the cells treated with carcinogenic 4-nitroquinoline 1-oxide was proposed to be either 3-(N⁶-adenyl)-4-aminoquinoline 1-oxide or 3-(N¹-adenyl)-4-aminoquinoline 1-oxide.

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