著者所属：Research Laboratory Department of Pharmaceutical Services University of Tokyo Hospital Research Laboratory Department of Pharmaceutical Services University of Tokyo Hospital Research Laboratory Department of Pharmaceutical Services University of Tokyo Hospital Faculty of Pharmaceutical Sciences University of Chiba
A simple and reliable method was devised for investigating the effect of another drug on pharmacokinetic parameters of a drug in the rat. This consists of the cannulation technique repeated after a suitable interval in the same rat. The effect of phenobarbital on the elimination of diphenylhydantoin was presented as a typical example.
