1975 Volume 23 Issue 3 Pages 543-551
The influence of chelating agents such as EDTA disodium salt and tetracycline hydrochloride, and surfactants such as sodium lauryl sulfate, sodium desoxycholate, sodium taurocholate, benzethonium chloride, polysorbate 80, HCO-50, and Pluronic F 68, upon the intestinal mucosa was investigated by measuring the apparent exsorption rate constant (K) of sulfaguanidine administered intravenously in the rat. Except Pluronic F 68, all the agents showed increase in K with concomitant histological change. Because of this histological change the permeability of sulfaguanidine from the blood vessel to the intestinal lumen was found to increase. Further, the value of K and its change with time are suggested to be usable as an indicator of the damaging effect of drugs on the intestinal mucosa.