抄録
Effect of antidepressants on the locomotor activity in paired young chicks was examined in comparison with that of other psychotropic drugs. Tricyclic antidepressants, imipramine, chlorimipramine, amitriptyline and nortriptyline caused an increase in locomotor activity together with hyperactivity. PF-82 and cocaine, uptake inhibitors, also caused a similar increase of the locomotor activity and behavioral changes to those of tricyclic antidepressants. On the other hand, behavioral effects of pargyline, iproniazid, methamphetamine, diazepam and chlordiazepoxide were different from those of tricyclic antidepressants. Chlorpromazine increased the locomotor activity in a manner similar to that of imipramine. Phentolamine, α-adrenergic blocking agent, however, caused little or no effects on the locomotor activity and behavioral changes. The locomotor activity increased by imipramine or chlorpromazine was inhibited by phentolamine. These results suggest an involvement of the uptake inhibition of central adrenergic neurones in connection with the increase in chick locomotor activity.
