Studies on Peptides. LXVIII. Synthesis of the Tritriacontapeptide Amide corresponding to the Entire Amino Acid Sequence of the Desulfated Form of Porcine Cholecystokinin-Pancreozymin (CCK-PZ)

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The tritriacontapeptide amide, [27-Tyr]-CCK-PZ, was synthesized by successive azide condensation of 4 peptide fragments, (1-5), (6-11), (12-16), and (17-33), followed by exposure to hydrogen fluoride to remove all protecting groups. Though the CCK-PZ activity of synthetic peptide was only 1/250 of the standard from the natural source, it was smoothly labeled with radioactive iodine. Chain length activity relationship of CCK-PZ was also discussed.