1976 年 24 巻 5 号 p. 1089-1093
The Diels-Alder reaction of 5-ethoxy-4-methyloxazole with unsymmetrical dienophiles was investigated and it was found that steric interaction during the course of the Diels-Alder reaction of an unsymmetrical dienophile with oxazole affected the structural isomeric distribution of the resulting products. On the basis of the above result, α4-norpyridoxol has been synthesized by the Dields-Alder reaction of 5-ethoxy-4 methyloxazole with allyl alcohol or its derivatives. With the latter, acid hydrolysis of the adduct was necessary to obtain the title compound.