Microbiological Transformation of (-)-Kaur-16-en-19-oic Acid

Abstract

(-)-Kaur-16-en-19-oic acid (I) is transfered by Cunninghamella blakesleeana to a series of differently hydroxylated derivatives, four compounds of which have been isolated and characterized as 7β-hydroxy-(-)-kaur-16-en-19-oic acid (II), 16-hydroxy-(-)-kauranoic acid (III), 16α, 17-dihydroxy-(-)-kauran-19-oic acid (IV) and 7β, 16α-dihydroxy-(-)-kauran-19-oic acid (V).