Pharmacological Activity of Propantheline Bromide mixed with Antacids in Guinea-pigs and Human

Abstract

The pharmacological effect of propantheline bromide (PB) mixed with dried aluminum hydroxide gel (DAHG) was investigated in guinea-pigs and human. In guinea-pigs, antimuscarinic effect was tested in their isolated ileums, and in human, salivary secretion was measured by Herxheimer. It was found that coadministration of PB together with DAHG resulted in a loss of potency of PB due to degradation, and thus the effects of powdered preparations of PB mixed with DAHG were merely those of antacids alone. But antimuscarinic agents kept away from antacids showed no change in their efficacy.