An apparent oral toxicity of 18-crown-6 (1, 4, 7, 10, 13, 16-hexaoxacyclooctadecane) and sulfamonomethoxine (SMM)/18-crown-6 complex in dogs was investigated following the bioavailability study of SMM/18-crown-6 complex which the authors reported already. When 18-crown-6 or SMM/18-crown-6 complex was administered orally to healthy beagle dogs, the following symptoms appeared : a tremulous movement, a salivation and a paralysis of hind legs at 2-12 hr after administration. These symptoms disappeared at 24 hr after administration.
