Synthesis of Compounds related to Antitumor Agents. VI. The Conversion of 2, 4-Dialkoxypyrimidines into N-Dialkyl-1, 2, 3, 4-tetrahydro-2, 4-dioxopyrimidines in the Presence of p-Toluenesulfonic Acid Derivatives

Abstract

The conversion of 2, 4-dialkoxypyrimidines into 1, 3-dialkyl-1, 2, 3, 4-tetrahydro-2, 4-dioxopyrimidines was brought about in the presence of p-toluenesulfonic acid derivatives by simple heating. This reaction seems to proceed stabilized transition state in p-toluenesulfonic acid derivatives, and may give rise to a nucleophilic reaction by nitrogen on the migrating alkyl group.