Amino Acids and Peptides. XXV. Phosphorus in Organic Synthesis. XIV. Application of Diphenyl Phosphorazidate (DPPA) to the Synthesis of the N-Terminal Hexapeptide of the Vasoactive Intestinal Peptide

Abstract

The synthesis of the N-terminal hexapeptide of the vasoactive intestinal peptide (VIP), His-Ser-Asp-Ala-Val-Phe (II) was carried out by the both fragment condensation and stepwise elongation approaches using mainly diphenyl phosphorazidate (DPPA) as a coupling reagent.