Hypocholesterolemic Action of Tricyclic Diterpenoids in Rats

HIROSHI ENOMOTO; YOSHIAKI YOSHIKUNI; YASUO YASUTOMI; KATSUYA OHATA; KENJI SEMPUKU; KOJI KITAGUCHI; YUKIO FUJITA; TAMIKI MORI

doi:10.1248/cpb.25.507

HIROSHI ENOMOTO, YOSHIAKI YOSHIKUNI, YASUO YASUTOMI, KATSUYA OHATA, KENJI SEMPUKU, KOJI KITAGUCHI, YUKIO FUJITA, TAMIKI MORI

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Keywords: totarol

JOURNAL FREE ACCESS

1977 Volume 25 Issue 3 Pages 507-510

DOI https://doi.org/10.1248/cpb.25.507

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Abstract

Various tricyclic diterpenoid derivatives of totarol, abietane and pimarane groups were found to have serum cholesterol lowering action in rats. Inhibition of intestinal cholesterol absorption was suggested to be involved in the main mechanism of hypocholesterolemic action of totarol and abietic acid.

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