Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
The Radioimmunoassay for Methamphetamine
稲山 誠一徳永 友喜子細谷 英吉中館 映夫丹羽口 徹吉
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キーワード: antihyptonic
ジャーナル フリー

1977 年 25 巻 4 号 p. 840-842

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抄録
The radioimmunoassay for methamphetamine (I) in urine of man has been established by use of the 125I-labelled derivative of N-[3-(p-hydroxyphenylacetylamino) propyl]-methamphetamine (V) in sensitivity of 8.0 ng/100μl. The antigen binding capacity of the antiserum prepared form N-carboxymethylmethamphetamine-BSA (II) was determined by a new method of immunoassay using fluorescence labelled N-(3-dansylaminopropyl) methamphetamine (IV) ("fluoroimmunoassay"). The specificity of the antibody was examined by its cross reaction with several methamphetamine analogues.
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© The Pharmaceutical Society of Japan
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