Electrophilic Substitution of 1, 2-Benzisothiazol-3-acetic Acid

Abstract

The bromination, the nitration, the chlorosulfonation, the formylation and the Mannich reaction of 1, 2-benzisothiaizol-3-acetic acid (1) were investigated and it was shown that the 3α-methylene group is also activated to the electrophilic substitutions as in 1, 2-benzisoxazol-3-acetic acid.