Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on Peptides. LXXV. Synthesis of the Hexadecapeptide corresponding to the Entire Amino Acid Sequence of β-Melanocytestimulating Hormone from the Dogfish (Squalus acanthias)
HARUAKI YAJIMA, JUN IWAI, KANAME KOYAMA, MASUHISA NAKAMURA, KENJI MIYATA, AKIRA TANAKA
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Keywords: condensation reaction in the absence of Et3N salt
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1978 Volume 26 Issue 2 Pages 571-578

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Abstract
In a conventional manner, the hexadecapeptide corresponding to the entire amino acid sequence of dogfish β-MSH (Squalus acanthias) was synthesized using protecting groups removable by hydrogen fluoride. The synthetic peptide exhibited the in vitro MSH activity of 1.88×109 MSH U/g.
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© The Pharmaceutical Society of Japan
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