Effect of Amphetamine on Kyunrenine Aminotransferase and Kynurenine Hydrolase Activities in Normal Mouse Liver

Abstract

Amphetamine inhibited (E. C. 2. 6. 1. 7) kynurenine aminotransferase and (E. C. 3. 7. 1. 3) kynurenine hydrolase in mouse liver homogenates. It has been suggested that the inhibitory effect of amphetamine was due to formation of Schiff's base with pyridoxal phosphate, causing a reduction in the level of free pyridoxal phosphate, which is a co-factor for both enzymes. The inhibitory effect of amphetamine for both enzymes is of the competitive type.