Synthesis of the Alkaloid from Thermoactinomyces Species

Abstract

The (S)-(+)-acid (3) obtained from (S)-(+)-alanine is protected the amino group with the benzyloxycarbonyl group and is combined with tryptamine to give the (S)-amide-urethane (5). Hydrogenolysis of 5 affords the (S)-(-)-amide (6) which is identified as the alkaloid (1) obtained from Thermoactinomyces strain TM-64.