Synthesis of Platinum (II) Complexes of 4-Substituted o-Phenylenediamine Derivatives and Determination of Their Antitumor Activity

Abstract

Pt (II) complexes of 4-substituted o-phenylenediamine (opda-R ; R=CH₃, OCH₃, H, Cl, COOH, NO₂, and SO₃H), PtX₂ (opda-R), were synthesized and tested for antitumor activity against P-388 leukemia. The infrared spectra of those complexes were analyzed to assign the Pt-N stretching vibrations on the basis of the halogeno trans effect and Hammett's σ values. The assigned Pt-N strectching vibrations were related to the antitumor activities of the opda-R Pt (II) complexes.