The Effects of Synthetic Glucagon Fragments on Glucose-6-phosphate Dehydrogenase. II

Abstract

The glucagon fragment H-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH (positions 22-29) was synthesized by a conventional method. Two glucagon fragments, H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-OH (positions 1-14) and the octapeptide fragment synthesized in this study were tested for inhibitory activity towards glucose-6-phosphate dehydrogenase. The octapeptide (positions 22-29) inhibited glucose-6-phosphate dehydrogenase activity by 18% at a concentration of 0.5 mg/ml.