Abstract
Changes in reference enzyme activities of subcellular particles of the rat kidney cortex were followed during periods of sodium restriction. Animals were maintained on a sodium-deficient diet for 28 days. Dietary sodium deprivation resulted in a marked decrease in daily urinary excretion of sodium and potassium from the second day, although the urine volume did not change significantly. The kidney cortex homogenate of sodiumrestricted rats was analyzed for the activities of reference enzymes. Acid phosphatase (lysosomal enzyme) and succinate dehydrogenase (mitochondrial enzyme) activities, and protein concentration remained unchanged throughout the experimental period. However, increases in the specific activities of glucose-6-phosphatase (microsomal enzyme), D-amino acid oxidase and catalase (peroxisomal enzymes) were observed after the 7th day of experiments.
