Sustained Release of Theophylline from Konjac Gels

Abstract

The possible use of konjac gels to achieve sustained release of theophylline on oral administration was examined in vitro. Theophylline was trapped in the gels by soaking the gels in a hot drug solution and subsequently drying them. Sustained release of the drug from the dried konjac gels was obtained. No marked difference was observed in the release patterns in the range of pH values expected in the gastrointestinal tract, and the drug contained in the gels was completely released.