Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Use of Rabbits for GI Drug Absorption Studies : Physiological Study of Stomach-Emptying Controlled Rabbits
TADAO MAEDAHIROSHI TAKENAKAYOSHIYA YAMAHIRATAKESHI NOGUCHI
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1979 Volume 27 Issue 12 Pages 3066-3072

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Abstract
The effect of stomach-emptying control on the physiological state of rabbits was examined. An improved"cangue method"for stomach-emptying control is described and compared with the previously reported"muzzle method."The increment of rabbit body weight indicated that pre-feeding of the special solid diet to rabbits in both methods did not affect their physiological state. Physiological normality of these rabbits was also confirmed in terms of urine pH and packed cell volume. The cangue method was found to be superior to the muzzle method as regards easy operation, the prevention of coprophagy and negligible damage to the stomach during the process of gastric lavage. Analysis of hemocytological and clinico-biochemical data suggested that the physiological state of rabbits is hardly affected by stomach-emptying control using either method.
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© The Pharmaceutical Society of Japan
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