The Effect of a Synthetic Thymosin α₁ Fragment on the Inhibition of E-rosette Formation by the Serum of a Patient with Nephrotic Syndrome

Abstract

The decapeptide corresponding to the C-terminal amino acid sequence (residues 19-28) of bovine thymosin α₁ was synthesized using HONB-WSCI as a coupling reagent. After incubation of lymphocytes with various amounts of the decapeptide from 10 to 100 μg/ml in the presence of serum from a patient with nephrotic syndrome, recovery of E-rosette formation was observed.