Synthesis of an Octacosapeptide Amide corresponding to the Entire Amino Acid Sequence of Chicken Vasoactive Intestinal Polypeptide (VIP)

HARUAKI YAJIMA; MASAHARU TAKEYAMA; KANAME KOYAMA; TAKAYOSHI TOBE; KAZUTOMO INOUE; TAMOTSU KAWANO; HIDEKI ADACHI

doi:10.1248/cpb.27.3199

HARUAKI YAJIMA, MASAHARU TAKEYAMA, KANAME KOYAMA, TAKAYOSHI TOBE, KAZUTOMO INOUE, TAMOTSU KAWANO, HIDEKI ADACHI

Author information

Keywords: vasodilator action of synthetic chicken VIP

JOURNAL FREE ACCESS

1979 Volume 27 Issue 12 Pages 3199-3201

DOI https://doi.org/10.1248/cpb.27.3199

Details

Abstract

The octacosapeptide amide corresponding to the entire amino acid sequence of chicken vasoactive intestinal polypeptide (VIP) was synthesized using a new arginine derivative, N^G-mesitylene-2-sulfonylarginine. A great tendency of ring closure in the Asp-Asn sequence during the acidolytic deprotection was noted.

Corresponding author

Register with J-STAGE for free!