Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Arylindoles. II. N-Arylindole-3-carboxaldehydes and Their Derivatives
MISBAHULAIN KHANEMELYKAZAN ROCHA
著者情報
キーワード: Vilsmeier-Haack formylation
ジャーナル フリー

1979 年 27 巻 2 号 p. 528-531

詳細
抄録
1-Phenyl-, and 1-nitrophenylindoles were subjected to the Vilsmeier-Haack reaction to give the corresponding 1-arylindole-3-carboxaldehyde in good yield. These aldehydes were condensed with nitromethane and hydroxylamine. The oximes were dehydrated to afford the 1-arylindole-3-carbonitriles (3b-3d). The Knoevenagal condensation of 1d with ethyl cyanoacetate gave 5d as a 1 : 1 mixture of cis and trans isomers.
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© The Pharmaceutical Society of Japan
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