Synthesis of N-Nitrosamino Aldehydes, Metabolic Intermediates possibly involved in the Induction of Tumors in Rats by N-Butyl-N-(ω-hydroxyalkyl) nitrosamines

Abstract

Three N-nitrosamino aldehydes, N-butyl-N-(ω-formylalkyl) nitrosamines, which are necessary metabolic intermediates situated between N-butyl-N-(ω-hydroxyalkyl)-nitrosamines and N-butyl-N-(ω-carboxyalkyl) nitrosamines were synthesized for the purpose of investigating their mutagenic effects.