1979 Volume 27 Issue 9 Pages 2016-2020
The monoester compositions of nine new sucrose fatty acid ester preparations produced industrially, which contain mono-, di-, and polyesters of stearic and palmitic acids in different ratios, were quantitatively analyzed by gas-liquid chromatography. Monoester-rich preparations had a marked cell growth inhibiting effect upon L-5178Y, as determined by the tissue culture method. It was observed that the ID50 values tend to decrease with increase in HLB (hydrophile-lipophile balance) values. These preparations were effective against Ehrlich ascites carcinoma as determined by the total packed cell volume method. Preparations consisting mainly of monoesters increased the life spans of mice bearing Ehrlich ascites tumor, but were not effective against L-1210.
