The Chemistry of Lactim Ethers. II. Reaction of Lactim Ethers with 2-Carbethoxymethyl Piperidines

Abstract

Annulation reactions of methyl valelolactim (2) and methyl caprolactim (3) with cyclic β-aminoesters, such as 2-carbethoxymethyl piperidine derivatives (4 or 5), often gave two kinds of products apparently arising from the imine and enamine forms of 2 and 3. These chemical properties were consistent with NMR observations of lactim ethers in CD₃OD solution.