Novel Diterpenelactones with Anti-peptic Ulcer Activity from Croton sublyratus

Abstract

Five novel furanoditerpenes of the ent-clerodane type, plaunol A (1), B (2), C (3), D (4) and E (5), were isolated from a fraction of Croton sublyratus KURZ extract with potent anti-Shay ulcer activity. Their absolute structures were determined from the spectral data and by chemical correlations.