抄録
When methyl, ethyl or n-propyl N-hydroxycarbamate was administered to rats intraperitoneally, the corresponding alkyl carbamate was detected as a urinary metabolite by thin-layer chromatography. These alkyl N-hydroxycarbamates were also converted to the corresponding alkyl carbamates by rat liver slices, but not by rat liver 9000 g supernatant. This suggests that the reduction of alkyl N-hydroxycarbamates may be catalyzed by liver enzymes which are different in nature from aromatic hydroxylamine-reducing enzymes. Similarly, the metabolism of ethyl carbamate in rats was investigated in vivo and in vitro. However, no ethyl N-hydroxycarbamate could be detected in these experiments. Therefore, it appears unlikely that alkyl N-hydroxycarbamates are metabolites of the corresponding alkyl carbamates in rats.
