Codeine-7, 8-oxide (4, 5α-Epoxy-7β, 8β-epoxy-3-methoxy-17-methylmorphinan-6α-ol) : Identification as a Metabolite of Codeine

抄録

The metabolism of codeine (1) by rat liver microsomal suspension was investigated. Codeine-7, 8-oxide (2) was identified as a new metabolite of 1 by gas chromatography-mass fragmentography and high-pressure liquid chromatography.