2-(Alkylthio) penem-3-carboxylic Acids. II. Chemical Manipulation of Penem Side Chains

抄録

The tert-butyldimethylsilyl group was found to be effective for protection of the hydroxyl group in penem synthesis. Manipulation of the side-chain hydroxyl group of base-sensitive penem-3-carboxylates was successfully conducted by means of a displacement reaction using a combination of triphenylphosphine-diethyl azodicarboxylate in the presence of a nucleophile.