Author's Organization：Faculty of Pharmaceutical Sciences, University of Tokyo Faculty of Pharmaceutical Sciences, University of Tokyo Faculty of Pharmaceutical Sciences, University of Tokyo
After oral administration of fluorescein to rabbits and human subjects, the urinary metabolites were examined. Two new metabolites, fluorescin and fluorescin monoglucuronide, were identified in addition to the main metabolite, fluorescein monoglucuronide. In both conjugates, glucuronic acid was found to be linked to a phenolic OH group iva an ether bond.
