Abstract
Two tetradecapeptides, Z-Leu-Gly-Cys (Bzl)-Gln-Ile-Cys (Bzl)-Leu-Thr-Lys (Z)-Ala-Met-Asp (OBzl)-Asn-Met-OH (I) and its benzyl ester (VIII) were synthesized. I was synthesized by the condensation of two heptapeptides [Z-Leu-Gly-Cys (Bzl)-Gln-Ile-Cys (Bzl)-Leu-NHNH2 (II) and Boc-Thr-Lys (Z)-Ala-Met-Asp (OBzl)-Asn-Met-OH (III)], while VIII was synthesized stepwise by the condensation of 4 fragments [Z-Leu-Gly-Cys (Bzl)-Gln-OH (XI), Boc-Ile-Cys (Bzl)-Leu-OH (X), Boc-Thr-Lys (Z)-Ala-NHNH2 (IV) and Boc-Met-Asp (OBzl)-Asn-Met-OBzl (IX)]. Deblocked I and deblocked VIII each formed a chelate with iron and sulfur.
