Synthesis of the Docosapeptide corresponding to the Amino Acid Sequence of Ostrich-type Corticotropin-like Intermediate Lobe Peptide (CLIP)

Abstract

The docosapeptide, H-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Val-Gln-Glu-Glu-Thr-Ser-Glu-Gly-Phe-Pro-Leu-Glu-Phe-OH, corresponding to positions 18 to 39 of ostrich ACTH (ostrich-type corticotropin-like intermediate lobe peptide, ost-CLIP), was synthesized, using 1M trifluoromethanesulfonic acid-thioanisole in TFA as a deprotecting reagent.