Abstract
The mutagenicity of several N-nitroso compounds, RCONHCH2N(NO)R', which were reported as new diazoalkane-generating agents, was assayed by the Salmonella/microsome test. Among 6 amide type N-nitroso compounds which had an alkyl group at position R, only two which had a benzyl group at position R'were weakly mutagenic to Salmonella typhimurium TA100, a base-pair substitution strain, with metabolic activation by S-9 mix. On the contrary, 6 carbamate type N-nitroso compounds which had an alkoxy or benzyloxy group at position R showed considerable mutagenic activity for TA100 with metabolic activation. Two of the carbamate type compounds which had a benzyl group at position R'were also mutagenic in Salmonella typhimurium TA98, a frameshift strain, even without metabolic activation.
