Author's Organization：Laboratories of Medicinal Chemistry, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd. Laboratories of Medicinal Chemistry, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd. Laboratories of Medicinal Chemistry, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd. Laboratories of Medicinal Chemistry, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd. Laboratories of Medicinal Chemistry, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.
5, 8-Dihydroxy-3, 4-dihydrocarbostyril, a key intermediate for the synthesis of β1-selective 8-acetonyloxy-5-[3-(3, 4-dimethoxyphenethylamino)-2-hydroxypropoxy]-3, 4-dihydrocarbostyril hydrochloride (opc-1427) was prepared from 2, 5-dimethoxyaniline.
