A NEW SYNTHETIC METHOD FOR 5'-TRIPHOSPHORYL-ADENYLYL-(2'-5')-ADENYLYL-(2'-5')-ADENOSINE (2-5A) AND 2-5A CORE USING 3'-O-TETRAHYDROFURANYL-ADENOSINE DERIVATIVES

Abstract

2' or 3'-O-Tetrahydrofuranyl derivatives of ribonucleosides have been synthesized by treating 2, 3-dihydrofurane with bis tert-butyldi-methylsilyl N-protected nucleosides. Using 3'-O-tetrahydrofuranyl-N-benzoyladenosine as the starting meterial 5'-phosphoryladenylyl-(2'-5')-adenylyl-(2'-5')-adenosine was synthesized in a good yield and converted to the triphosphoryl derivative (2-5A). The 2'-5' linked triadenylate (2-5A core) was also prepared by the same phosphotriester method.