SYNTHESIS OF (±)-CARBA-ANALOGS OF 5-HPETE AND LEUKOTRIENE A4, UNSTABLE INTERMEDIATES OF SLOW-REACTING SUBSTANCE (SRS)

Yoshinobu Arai; Mitoshi Konno; Katsuichi Shimoji; Yoshitaka Konishi; Haruki Niwa; Masaaki Toda; Masaki Hayashi

doi:10.1248/cpb.30.379

SYNTHESIS OF (±)-CARBA-ANALOGS OF 5-HPETE AND LEUKOTRIENE A₄, UNSTABLE INTERMEDIATES OF SLOW-REACTING SUBSTANCE (SRS)

新井義信, 金野美登志, 下地克一, 小西由高, 丹羽治樹, 戸田正明, 林正樹

著者情報

キーワード: analog of leukotriene A₄

ジャーナルフリー

1982 年 30 巻 1 号 p. 379-382

DOI https://doi.org/10.1248/cpb.30.379

詳細

抄録

The carba-analogs of 5-HPETE and leukotriene A₄, unstable intermediates of slow-reacting substance (SRS), were synthesized. These carbaanalogs inhibited the 5-lipoxygenase. The carba-analog of leukotriene A₄ was a particularly potent specific inhibitor of the 5-lipoxygenase.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）