抄録
Two series of 8-acetyl-12-hydroxyalkadienoic acids and 14-hydroxy-9-oxoalkadienoic acids, which can be regarded as 11, 12-and 8, 12-secoprostaglandin E2, were synthesized and evaluated for biological activity on platelet function. Key members of each series, 11, 12-and 8, 12-seco-11-norprostaglandin E2, were found to induce platelet aggregation. This effect was inhibited by preincubation of PRP with prostaglandin I2 but was not inhibited by indomethacin.
